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Zero Exosome line
Choose Mild 2000 or Strong 7500
A spicule serum for pore and texture care, with Mild 2000 and Strong 7500 options for different experience levels.
Both options use exosome-coated spicules for focused pore and skin-texture care. Select the strength that fits your experience and skin comfort.

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Understand the tingling sensation
Spicule skincare can feel prickly during application. Begin with a small amount of Mild 2000, and stop use if irritation persists or becomes uncomfortable.

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Exosome-coated spicules
The formula combines hydrolyzed sponge with Lactobacillus extracellular vesicles. These ingredients create the distinctive spicule-serum application experience.

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A focused pore-care step
Use this treatment before a gentle moisturiser when uneven-looking texture and visible pores are your priorities.

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Lacto exosome care
Lactobacillus extracellular vesicles sit alongside niacinamide, panthenol and humectants in the formula.

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A distinctive spicule texture
Exosome-coated spicules create a temporary prickling feel. Apply gently without prolonged rubbing.

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Keep the rest of your routine simple
Pair the serum with comfortable hydration. Introduce one intensive treatment at a time so you can judge your skin’s response.

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Hydrolyzed sponge
Hydrolyzed sponge is the spicule ingredient in this serum. Avoid the eye and lip areas, and patch test before first use.

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Two strengths in this listing
Choose Mild 2000 for your first spicule routine or Strong 7500 for a three-day cycle once accustomed. The 25000 option in the comparison is not offered in this listing.

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Absorption testing for Mild 2000
In the comparison shown, the 2000 serum improved absorption of the accompanying skincare by 242% versus applying that skincare alone.

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A treatment before moisture care
Apply the serum before your moisturiser. The absorption result shown relates to the tested routine with the 2000 strength.

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Visible pore and texture care
Testing recorded improvements in pore appearance, surface texture and hydration. The visual shows the measured areas and the skin appearance examples.

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Follow the right use cycle
Mild 2000 can be used daily as tolerated; Strong 7500 follows a three-day cycle. Do not layer both strengths in the same session.

How to use
Make it part of your routine
Choose your strength
Start with Mild 2000 if you are new to spicule skincare. Strong 7500 is for experienced users and is used on a three-day cycle.
Apply gently
After cleansing, apply a small amount while avoiding the eyes and lips. Gently press and spread; do not scrub.
Moisturise
Finish with a gentle moisturiser. Use sunscreen during the day and reduce frequency if skin feels uncomfortable.
Complete Your Routine
Explore the Zero line
Choose a cleanser, toner option, treatment and moisturiser. Sunscreen completes daytime care. Peels and masks are optional; avoid combining several exfoliating steps in one routine.




Zero Pore Blackhead Mud Mask 100g
An optional treatment; follow its specific directions.
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Zero Pore Blackhead Deep Cleansing Oil 205ml
A cleanser option for the start of your routine.
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Zero Pore Moisture Sun Serum SPF 50+ PA++++ 50ml
A treatment option before moisturiser.
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Zero Pore SA Clear Capsule Cleansing Foam 120g
A cleanser option for the start of your routine.
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One Day Exosome Shot Mild 2000 | Strong 7500 (30ml)
A treatment option before moisturiser.
View product →Product details
Product Specifications
- Product
- Medicube One Day Exosome Shot Mild 2000 | Strong 7500 (30ml)
- Size
- 30ml per bottle
- Made in
- South Korea
- Product form
- Serum
- Packaging
- Bottle
- Skin types
- Combination, Normal, Oily
- Key ingredients
- Hydrolyzed sponge, Lactobacillus extracellular vesicles, niacinamide, panthenol, AHA/BHA/PHA
Full Ingredients
2000 | Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, C12-14 Alketh-12, Hydrogenated Polydecene, Hydrolyzed Sponge, Ethylhexylglycerin, Adenosine, Caprylyl/Capryl Glucoside, Disodium EDTA, Panthenol, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis (Evening Primrose) Flower Extract, Ulmus Davidiana Root Extract, Calcium Silicate, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
7500 | Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl/Capryl Glucoside, Disodium Edta, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis (Evening Primrose) Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
Storage and Safety
For external use. Avoid eyes, lips, broken skin and irritated skin. Patch test first and begin with Mild 2000. A prickling sensation can occur; stop if irritation persists. Do not layer strengths. Beginners should avoid combining it with AGE-R devices. Use sunscreen during the day.
Frequently asked questions
What does this product do?
A spicule serum for pore and texture care, with Mild 2000 and Strong 7500 options for different experience levels.
What are the key ingredients?
Hydrolyzed sponge, Lactobacillus extracellular vesicles, niacinamide, panthenol, AHA/BHA/PHA.
How do I use it?
Start with Mild 2000 if you are new to spicule skincare. Strong 7500 is for experienced users and is used on a three-day cycle. After cleansing, apply a small amount while avoiding the eyes and lips. Gently press and spread; do not scrub. Finish with a gentle moisturiser. Use sunscreen during the day and reduce frequency if skin feels uncomfortable.
Which skin types is it for?
Combination, Normal, Oily. Patch test and introduce gradually if your skin is sensitive.
How does it fit into my routine?
Choose a cleanser, toner option, treatment and moisturiser. Sunscreen completes daytime care. Peels and masks are optional; avoid combining several exfoliating steps in one routine.
Which strengths can I choose?
Choose Mild 2000 or Strong 7500, each 30ml. The combo option contains both strengths. Use one strength per application; do not layer them together.
What is the current stock and delivery status?
Ready Stocks In Singapore. Delivery: 1–3 Working Days. Allow one working day for order processing; courier delivery excludes weekends and public holidays.
Medicube at COCOMO
Medicube One Day Exosome Shot Mild 2000 | Strong 7500 (30ml) in Singapore
Shop Medicube One Day Exosome Shot Mild 2000 | Strong 7500 (30ml) at COCOMO. A spicule serum for pore and texture care, with Mild 2000 and Strong 7500 options for different experience levels. Explore the Medicube collection to build a routine around your skin’s needs.

















